2,208
次編輯
變更
戚正武
,無編輯摘要
{{Infobox person| 生物化 姓名 = 戚正武| 图像 = [[File:戚正武.jpg|缩略图|center|[http://www.casad.cas.cn/wcm/sourcedb_ad_cas/zw2/json/smkxhyxxb/200906/W020100511740886762865.jpg 原图链接][http://www.casad.cas.cn/chnl/374/index.html 来自中国科学院 学 家 部]]]| 男，1932 出生日期 = 1932 年4月 生， 浙江宁波 人。1952年毕 | 国籍 = 中国| 民族 = 汉| 职 业 于 = 生物化学家| 母校 = 同济大学 ，1959年获苏联医学科学院莫斯科医学生物化学 | 研究 所副博士学位。1999年当选为中国科学院院士。现为中国科学院上海生命科 领域 = <br>医 学 研究院研究员。}}
<big>'''戚正武 '''</big><ref>[http://www.casad.cas.cn/aca/374/smkxhyxxb-200906-t20090624_1803219.html ]中国科学院 </ref>><br>
* 生物化学家 男，1932年4月生，浙江宁波人。1952年毕业于同济大学，1959年获苏联医学科学院莫斯科医学生物化学研究所副博士学位。1999年当选为中国科学院院士。现为中国科学院上海生命科学研究院研究员。<br>
== 人物经历 ==
* 1952年毕业于同济大学化学系；
* 1959年获苏联莫斯科医学科学院生物与医学研究所副博士学位；
* 1981-1982年以及1987年、1995年分别于美国Purdue 及Notre Dame大学进行学术交流。曾担任数届国际《血栓研究》杂志的编委，现任《中国科学》,《生物化学与生物物理学报》及其他国内多种学术期刊的编委。现兼同济大学蛋白质研究所所长及化学系主任；
* 1999年被评为中国科学院院士；
* 2001年被评为第三世界科学院院士。
== 研究方向及科研成果 ==
长期从事蛋白质、活性多肽、尤其是蛋白酶及其抑制剂的研究。系统研究了三种不同家族蛋白酶抑制剂的结构与功能，其中慈菇抑制剂为首先发现的新抑制剂家族，成为国际上研究蛋白酶抑制剂的重要研究中心之一。此外，协作克隆了凝血因子FVIII及vWF的全cDNA，并进行了表达。近年来又解析了中华马氏钳蝎毒素中多种Na+通道毒素的氨基酸序列及其基因结构，通过基因突变研究其结构与功能的关系，并开展了其它K+、Ca2+及Cl-通道神经毒素的研究。
== 主要奖项 ==
* 中科院自然科学一等奖一次，二等奖三次
* 国家自然科学三等奖二次
* 1981年慕尼黑国际激肽会议获优秀论文奖及其他省、部级多次科技奖
== 代表性论文 ==
# Yuan DD, Liu L, Shao XX, Peng C, Chi CW, Guo ZY. Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus. Peptides. 2008 Sep;29(9):1521-5. Epub 2008 May 25.
# Wang Q, Jiang H, Han YH, Yuan DD, Chi CW. Two different groups of signal sequence in M-superfamily conotoxins. Toxicon. 2008 Apr;51(5):813-22. Epub 2007 Dec 15.
# Qian J, Guo ZY, Chi CW. Cloning and isolation of a Conus cysteine-rich protein homologous to Tex31 but without proteolytic activity. Acta Biochim Biophys Sin (Shanghai). 2008 Feb;40(2):174-81.
# Rui-feng Qi, Ling Zhang, and Cheng-wu Chi. Biological characteristics of dengue virus and potential targets for drug design. Acta Biochim Biophys Sin. 2008 Feb;40(2):91-101.
# Wang ZQ, Han YH, Shao XX, Chi CW, Guo ZY. Molecular cloning, expression and characterization of protein disulfide isomerase from Conus marmoreus. FEBS J. 2007 Sep;274(18):4778-87. Epub 2007 Aug 14.
# Yuan DD, Han YH, Wang CG, Chi CW. From the identification of gene organization of alpha conotoxins to the cloning of novel toxins. Toxicon. 2007 Jun 15;49(8):1135-49. Epub 2007 Mar 1.
# Du WH, Han YH, Huang FJ, Li J, Chi CW, Fang WH. Solution structure of an M-1 conotoxin with a novel disulfide linkage. FEBS J. 2007 May;274(10):2596-602. Epub 2007 Apr 16.
# Han YH, Wang Q, Jiang H, Liu L, Xiao C, Yuan DD, Shao XX, Dai QY, Cheng JS, Chi CW. Characterization of novel M-superfamily conotoxins with new disulfide linkage. FEBS J. 2006 Nov;273(21):4972-82. Epub 2006 Oct 17.
# Chen-Qi Xu, Shun-Yi Zhu, Cheng-Wu Chi and Jan Tytgat. Turret and pore block of K+Channels: what is the different? Trends Pharmac. Sci. 24(9): 446-449, 2003.
# Fan CX, Chen XK, Zhang C, Wang LX, Duan KL, He LL, Cao Y, Liu SY, Zhong MN, Ulens C, Tytgat J, Chen JS, Chi CW, and Zhou Z. A novel conotoxin from conus betulinus, k-BtX, unique in cysteine pattern and in function as a specific BK channel modulator. J Biol Chem. 278(15), 12624-12633, 2003.
# Wang CG, Gilles N, Hamon A, Le Gall F, Stankiewicz M, Pelhate M, Xiong YM, Wang DC and Chi CW. Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis. Biochemistry. 42 (16), 4699-4708, 2003.
# Wang CG, Stankiewicz M, Ling MH, Pelhate M, Wang DC and Chi CW*. Purification of two depressant insect neurotoxins and their gene cloning from the scorpion Buthus martensi Karsch. J. Pept. Res. 61(1): 7-16, 2003.
# C. Goudet, Cheng-wu Chi, J Tytgat. An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch. Toxicon. 40(9), 1239, 2002.
# Jiong Li, Kang-cheng Ruan, Cheng-wu Chi. The assignment of the reactive sites of the double-headed arrowhead proteinase inhibitor A and B. Acta Biochi. Biophys Sinica. 34, 662, 2002.
# Jiong Li, Cheng-wu Chi, Kang-cheng Ruan. Conformation nearby Trp residues of APIA and APIB modulates the inhibitory specificity of the protease. Acta Biochi. Biophys Sinica. 34, 494, 2002.
# Jing-Jiang Wu, Lin-Lin He, Zhuan Zhou and Cheng-Wu Chi. Gene expression, mutation and structure-function relationship of scorpion toxin BmP05 active on SKCa channels. Biochemistry. 41, 2844, 2002
# Chun Chen, Qi Wang, Xiang-dong Fang, Qin Xu, Cheng-wu Chi and Jian-xin Gu. Roles of the phytanoyl CoA ?-hydroxylase in mediating the expression of human coagulation factor VIII. J. Biol. Chem. 276, 46340, 2001.
# Guang-yu Zhu, Qi-chen Huang, Yan-shi Zhu, Cheng-wu Chi, You-qi Tang. X-ray study on an artificial mung bean inhibitor complex with bovine ?-trypsin in neat cyclohexane. Biochim. Biophys. Acta 1546, 98, 2001.
# Chun-Guang Wang, Xiao-Lin He, Feng Shao, Wei Liu, Min-Hua Ling, Da-Cheng Wang, Cheng-Wu Chi. Molecular characterization of an anti-epilepsy peptide from the scorpio Buthus martensi Karsch. Eur. J. Biochem. 268, 2480, 2001.
# Xiang-Dong Fang, Chun Chen, Qi Wang, Jian-Xin Gu, Cheng-Wu Chi. The Interaction of the Calcium and Integrin Binding Protein (CIBP) with the Coagulation Factor VIII. Thromb. Res. 102, 177, 2001.
# Hao Fei, Yan LI, Li-Xiu Wang, Ming-Juan Luo, Min-Hua Ling, Cheng-Wu Chi. Purified nonhistone protein from porcine kidney acts as a suicide substrate inhibitor on furin-like enzyme. Acta Pharmacol. Sin. 21, 265, 2000.
# Li Dai, Jing-jiang Wu, Yi-hua Gu, Zheng-dao Lan, Min-hua Ling and Cheng-wu Chi. Genomic organization of three novel toxins from the scorpion Buthus martinsi Karsch that are active on potassium channels. Biochem. J. 346, 805, 2000.
# Jing-jiang Wu, Li Dai, Zheng-dao Lan and Cheng-wu Chi. The Gene Cloning and Sequencing of Bm-12, a Chlorotoxin-like Peptide from the Scorpion Buthus martinsi Karsch. Toxicon 38, 661, 2000.
# Feng Shao, Yu-mei Xiong, Rong-huan Zhu, Min-hua Ling, Cheng-wu Chi & Da-cheng Wang. Expression and Purification of the BmK M1 Neurotoxin from the Buthus martinsi Karsch. Protein Expression and Purification 17, 358, 1999.
# Yan-shi Zhu, Qi-chen Huang and Cheng-wu Chi. Crystal structure of mung bean inhibitor lysine active fragment complex with bovine beta-trypsin at 1.8A resolution. J Biomol Struct Dyn. 1999 Jun;16(6):1219-24.
# Chun Chen, Xiao-dong Fang, Jiang Zhu, Xiang-fu Wu, Zu-chuan Zhang, Zheng-yi Wang and Cheng-wu Chi. The Gene Expression of Coagulation Factor VIII in Mammalian Cell Lines. Thrombosis Res. 95, 105, 1999.
# Jing-jiang Wu, Li Dai, Zheng-dao Lan and Cheng-wu Chi. Genomic Organization of Three Neurotoxins Active on Small Conductance Ca++-activated Potassium Channels from the Scorpion Buthus martinsi Karsch. FEBS Letters 452, 360, 1999.
# Yu-mei Xiong, Zheng-dao Lan, Miao Wang. Bo Liu, Xin-qi Liu, Hao Fei, Lai-gen Xu, Qi-Chang Xia, Chung-guang Wang, Da-cheng Wang and Cheng-wu Chi. Molecular Characterization of a New Excitatory Insect Neurotoxin with an Analgesic Effect on Mice from the Scorpion Buthus martinsi Karsch. Toxicon 37, 1165, 1999.
# Zheng-dao Lan, Li Dai, Xiao-liang Zhuo, Ke Xu, Jun-Cai Feng and Cheng-wu Chi. Gene Cloning and Sequencing of BmK AS and BmK As-1, Two Novel Neurotoxins from the Scorpion Buthus martinsi Karsch. Toxicon. 37, 815, 1999.
# Yu-mei Xiong, Min-hua Ling, Zheng-dao Lan, Da-cheng Wang and Cheng-wu Chi .The cDNA Sequence of an Excitatory Insect Selective Neurotoxin from the Scorpion Buthus martinsi Karsch. Toxicon 37, 335, 1999.
# Yu-mei Xiong, Min-hua Ling, Da-cheng Wang and Cheng-wu Chi. The cDNA and Genomic DNA Sequences of a Mammalian Neurotoxin from the Scorpion Buthus martensii Karsch. Toxicon 35, 1025, 1997.
# Ming-juan Luo, Yu-mei Xiong, Miao Wang, Da-cheng Wang and Cheng-wu Chi. Purification and Sequence Determination of a New Neutral Mammalian Neurotoxin from Scorpion Buthus martensii Karsch. Toxicon 35, 723, 1997.
# Ming-juan Luo, Wu-yuan Lu and Cheng-wu Chi. Clarification of an Uncertain Intron within the cDNA Sequences of Arrowhead Proteinase Inhibitor A and B. J. Biochem. (Tokyo) 121, 991, 1997.
# Zhi-wei Xie, Ming-juan Luo, Wen-feng Xu and Cheng-wu Chi. Two Reactive Site Location and Structure-Function Study of the Arrowhead Protease Inhibitors,A and B, Using Mutagenesis. Biochemistry (US) 36, 5846, 1997.
== 参考资料 ==
{{Reflist}}
== 外部链接 ==
* [http://www.sibcb.ac.cn/pi.asp?id=126 戚正武简介 ]
* [http://news.hexun.com/2014-01-17/161506798.html 戚正武院士：我为什么要求除名王正敏 ]