唐铁山查看源代码讨论查看历史
| 唐铁山 |
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唐铁山，男，汉族，博士，研究员，博士生导师[1];中国科学院动物研究所分子神经生物学研究组组长[2]。
基本信息
人物说明----中国科学院动物研究所分子神经生物学研究组组长
民 族 ---- 汉族
国 籍 ---- 中国
职 业 ---- 教育科研工作者
主要成就----应聘入选中国科学院动物所"百人计划-国外引进杰出人才"
研究方向----神经细胞钙信号的功能调控
人物经历
2008年应聘入选中国科学院动物所"百人计划-国外引进杰出人才"，在生物膜和膜工程国家重点实验室建立"分子神经生物学研究组"。1998年于中国科学院发育生物学研究所分子发育开放实验室获得博士学位。2000年以后在美国得克萨斯大学西南医学研究中心生理系做博士后研究和讲师。
研究方向
主要研究方向为神经细胞在生理和病理状态下钙信号的功能调控。
主要贡献
Wang QC1, Zheng Q1, Tan H1, Zhang B1, Li X1, Yang Y, Yu J, Liu Y, Chai H, Wang X, Sun Z, Wang JQ, Zhu S, Wang F, Yang M, Guo C, Wang H, Zheng Q, Li Y#, Chen Q#, Zhou A*, Tang TS* (2016) TMCO1 is an ER Ca2+ load-activated Ca2+ (CLAC) channel。
Yi-Han Wang1, Jiu-Qiang Wang1, Qiaochu Wang1, Yun Wang, Caixia Guo, Quan Chen, Tuanyao Chai*, Tie-Shan Tang* (2016) Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy
Jinting Yan, Hui Zhang, Yang Liu, Feilong Zhao,。Shu Zhu, Tie-Shan Tang*, and Caixia Guo* (2016) Germline Deletion of Huntingtin Causes Male Infertility and Arrested Spermiogenesis in Mice
Wang Z, Huang M, Ma X, Li H, Tang TS*, 。Guo C* (2016) REV1 promotes PCNA monoubiquitination through interacting with ubiquitinated RAD18。
Yang Y#, Liu Z#, Wang F#, Temviriyanukul P, Ma X, Tu Y, Lv L, Lin YF, Huang M, Zhang T, Pei H, Chen BP, Jansen JG, de Wind N, Fischhaber PL, Friedberg EC, Tang TS*, Guo C* (2015) FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress。
Xiaoling Li, Hongmei Liu, Paula L. Fischhaber*, Tie-Shan Tang* (2015) Towards therapeutic targets for SCA3: insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance。
Qin Y, Guo T, Li G, Tang TS, Zhao S, Jiao X, Gong J, Gao F, Guo C, Simpson JL, Chen ZJ* (2015) CSB-PGBD3 Mutations Cause Premature Ovarian Failure. PLoS Genet。
Wenjuan Xie, Jiu-Qiang Wang, Qiao-Chu Wang, Yun Wang, Sheng Yao*, Tie-Shan Tang* (2015) Adult neural progenitor cells from Huntington's disease mouse brain exhibit increased proliferation and migration due to enhanced calcium and ROS signals。
Fengli Wang, Paula L. Fischhaber, Caixia Guo, Tie-Shan Tang* (2014) Epigenetic modifications as novel therapeutic targets for Huntington's disease。
Liu Y, Yang Y, Tang TS, Zhang H, Wang Z, Friedberg E, Yang W, Guo C*. (2014) Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct。
Xiaoling Li, Fengqin Qu, Wenjuan Xie, Fengli Wang, Hongmei Liu, Shuhui Song, Tingting Chen, Yang Zhang, Shu Zhu, Yun Wang, Caixia Guo, Tie-Shan Tang* (2014) Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal。
Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, Li X, Liu Z, Zhang T, Huang M, Friedberg E, Tang TS, Guo C*. (2013) Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation。
Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C * , Han C * , Tang TS * . (2013) Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease。
Xiuli Zhang#, Lingna Lv#, Qian Chen#, Fenghua Yuan, Ting Zhang, Yeran Yang, Hui Zhang, Yun Wang, Liangyue Qian, Benjamin Chen, Yanbin Zhang, Errol C Friedberg, Tie-Shan Tang*, Caixia Guo* (2013) Mouse DNA Polymerase Kappa Has A Functional Role in the Repair of DNA Strand Breaks。
Jiu-Qiang Wang, Qian Chen, Xianhua Wang, Qiao-Chu Wang, Yun Wang, He-Ping Cheng, Caixia Guo, Qinmiao Sun, Quan Chen, Tie-Shan Tang* (2013) Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington's Disease。
Zhifeng Wang#, Fengli Wang#, Tie-Shan Tang*, Caixia Guo* (2012) The role of PARP1 in the DNA damage response and its application in tumor therapy. Front Med。
Guo C, Tang TS, Friedberg EC. (2010) SnapShot: Nucleotide Excision Repair。
Hongyu Wang, Xi Chen, Yuemei Li, Tie-Shan Tang* and Ilya Bezprozvanny* (2010) Tetrabenazine is neuroprotective in Huntington's disease mice。
Guo C, Kosarek JN, Tang TS and Friedberg EC. (2009。
Tang, T.S., Guo, C., Wang, H., Chen, X., Bezprozvanny, I. (2009) Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model. J Neuroscience。
- Highlighted in: The Journal of Neuroscience Feb 4;29(5):i. i。
Chen, X., Tang, T.S., Tu, H., Nelson O., Pook, M., Hammer, R., Nukina, N., Bezprozvanny, I. (2008) Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3。
Schneider, J.W., Gao. Z., Li, S., Farooqi, M., Tang, T.S., Bezprozvanny, I., Frantz, D., Hsieh, J. (2008) Small molecule activation of neuronal cell fate。
Guo, C., Tang, T.S., Bienko, M., Dikic, I. and Friedberg E.C. (2008) Requirements for the Interaction of Mouse Polκ With Ubiquitin, and its Biological Significance。
Tang, T.S., Chen, X., Liu, J., Bezprozvanny, I. (2007) Dopaminergic signaling and apoptosis of medium spiny neurons in Huntington's disease. J。
Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg EC. (2006) REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo。
Guo C, Tang TS, Bienko M, Sonoda E, Parker JL, Bielen AB, Takeda S, Ulrich HD, Dikic I, Friedberg EC. (2006) Ubiquitin-Binding Motifs in Rev1 Protein are Required for Its Role in the Tolerance of DNA Damage
Wu, J., Tang, T.S., and Bezprozvanny, I. (2006) Evaluation of clinically-relevant glutamate pathway inhibitors in in vitro model of Huntington's disease。
Tang, T.S., Slow, E., Lupu, V., Stavrovskaya, I.G., Sugimori, M., Llinas, R., Kristal, B.S., Hayden, M.R., Bezprozvanny, I. (2005) Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease。
[This work has been reported or reprinted by Medical News Today, EurekAlert, Innovations Report, BETTERHUMANS, News-Medical in Medical Research News, Datamonitor NewsWire]。
Ying Chen, Uwe Beffert, Mert Ertunc, Tie-Shan Tang, Ege T. Kavalali, Ilya Bezprozvanny , Joachim Herz (2005) Reelin modulates NMDA receptor activity in cortical neurons。
Tang, T.S., Bezprozvanny, I. (2004) Dopamine receptor-mediated Ca2+ signaling in striatal medium spiny neurons。
Tu*, H., Tang*, T.S., Wang, Z., Bezprozvanny, I. (2004) Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A
Tang, T.S., Tu, H., Orban, P.C., Chan, E.Y., Hayden, M.R., Bezprozvanny, I. (2004) HAP1 facilitates effects of mutant huntingtin on inositol-(1,4,5) trisphosphate-induced Ca2+ release in striatal medium spiny neurons
Tang, T.S., Tu, H., Chan, E.Y., Maximov, A., Wang, Z., Wellington, C.L., Hayden, M.R., Bezprozvanny, I. (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) trisphosphate receptor type 1。
a) Anurag Varshney and Barbara E. Ehrlich (2003) Intracellular Ca2+ Signaling and Human Disease: The Hunt Begins with Huntington's。
b) Colin Taylor, University of Cambridge, UK (2003) The Scientist。
c) Faculty of 1000 Biology: evaluations for Tang TS et al。
Tang*, T.S., Tu*, H., Wang, Z., and Bezprozvanny, I. (2003) Modulation of the type 1 inositol (1,4,5)-trisphosphate receptor function by PKA and PP1-alpha。
Maximov*, A, Tang*,T.S., Bezprozvanny, I. (2003) Association of the Inositol (1,4,5)-trisphosphate receptors with 4.1N protein in neurons。
Tang, T.S., Dong, J.B., Huang, X.Y. and Sun, F.Z. (2000) Ca2+ oscillations induced by a cytosolic sperm protein factor are mediated by a maternal machinery which functions only once in mammalian eggs。
Dong, J.B., Tang, T.S. and Sun, F.Z. (2000) Xenopus and chicken sperm contain a cytosolic soluble factor which can trigger calcium oscillations in mouse eggs。
Dong, Y., Tang, T.S., Lu, C.L., He, C., Dong, J.B., Huang, X.Y., Sun, F.Z., Bao, X. (2000) Pituitary adenylate cyclase activating polypeptide ameliorates the damage and inhibits the increase of intracellular calcium concentration in cultured hippocampal neurons induced by glutamate。
Guo, C.X., Tang, T.S., and Liu, Y.X. (2000) Germ cell apoptosis and regulation in testis。
Guo, C.X., Tang, T.S., Mu, X.M., Li, S.H., Fu, G.Q., Liu, H. and Liu, Y.X. (1999) Cloning of novel temperature-related expressed sequence tags in rat testis during spermatogenesis
Deng, M.Q., Huang, X.Y., Tang, T.S. and Sun, F.Z. (1998) Spontaneous and fertiliz。ation-induced Ca2+ oscillations in mouse immature germinal vesicle-stage oocytes。
Tang, T.S. and Dou, Z.Y. (1993) Progress in establishment of embryonic stem (ES) cell lines from mammals. Acta Univ. Agric 。
在国际上首先发现了神经细胞胞内钙信号紊乱与亨廷顿氏神经退行性疾病(舞蹈病)的关系;并使用基因治疗的方法，稳定了舞蹈病模型小鼠神经细胞的钙信号，显著延缓了疾病模型小鼠纹状体神经细胞的退行性病变。 近年来所取得的研究成果发表在国际核心学术期刊，包括Neuron、PNAS、J Neuroscience、 Development、J Biol Chem等。迄今共发表SCI收录论文25余篇， 获得美国专利一项。今后的研究重点将以小鼠、果蝇和斑马鱼等模式动物作为研究体系，利用分子细胞生物学、遗传学和生物化学等技术，探讨神经钙信号紊乱，DNA的损伤修复与神经退行性疾病的关系;探索以神经钙信号传导通路，DNA的损伤与修复通路为切入点的神经退行性疾病治疗方案。作为项目负责人承担了中科院百人计划项目、中科院知识创新工程重要方向项目以及国家自然科学基金面上项目 。