楊麗聰檢視原始碼討論檢視歷史
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楊麗聰，女，福州大學生物科學與工程學院教授。
人物簡歷
2021.03-至今：福州大學，副教授
2018.11-2021.2：江西農業大學，副教授，青年教授
2015.07-2018.11：江西農業大學，講師，未來之星
2012.09-2015.06：暨南大學，生物化學與分子生物學，博士
研究方向
食品源多酚資源開發、納米材料製備及活性研究
科研項目
主持課題
1. 國家自然科學地區基金項目，21967010，基於不同負載作用力二氫楊梅素納米載藥體系的構建及其抑制阿爾茲海默症的研究，2020/01-2023/12，40萬元，在研，主持
2. 國家自然科學青年科學基金項目，21701068，多酚納米硒多肽靶向抑制Aβ聚集及減緩氧化應激活性的研究，2018/01-2020/12，23萬元，結題，主持
3. 江西省教育廳科學技術研究項目，GJJ180209，綠原酸納米多肽靶向透過血腦屏障抑制Aβ聚集的研究，2019/01-2020/12，3萬元，結題，主持
4. 江西省高校教改立項資助項目，JXJG-16-3-15，食品毒理學教學改革研究，2017/01-2019/ 12，5000元，結題，主持
5. 江西省科技計劃項目自然科學基金，20171BAB215074，白藜蘆醇修飾的納米硒抑制阿爾茲海默症中Aβ聚集及自由基生成的研究，2017/01-2018/12，6萬元，結題，主持
6. 江西省教育廳科學技術研究項目，GJJ160383，綠原酸修飾納米硒抑制Aβ聚集的體外研究，2017/01-2018/12，3萬元，結題，主持
參與課題
1. 第二參與人，中央財政農業技術推廣經費項目永新縣優質茶葉生產示範推廣項目研發經費，2018ZDF40010-5，2020/01-2020/12，5萬元，結題；
2. 第二參與人，國家自然科學基金，81760157，基於AMPK信號通路研究菝葜黃酮調控脂類代謝分子機制，2018/01-2021/12，32萬元，在研；
3. 第二參與人，國家自然科學基金，31760461，龜苓膏中黃酮「落新婦苷」與蛋白質相互作用機制及對其穩定性和生物利用度的影響，2018/01-2021/12，38萬元，在研；
4. 第三參與人，國家自然科學基金，31660486，新型抗A0Z/AMOZ雙特異性單鏈抗體的構建及其多殘留同時免疫分析方法研究，2017/01-2020/12，39萬元，結題；
5. 第二參與人，江西省自然科學基金項目，20142BAB204003，咖啡鹼和綠原酸對高脂飲食誘導肥胖小鼠脂肪代謝相關基因和蛋白表達的影響，2014.01-2015.12，5萬元，結題。
6. 第二參與人，江西省教育廳科學技術研究項目，GJJ160414，天然紫色桿菌素（Violacein） 微生物生成能力的關鍵蛋白結構的研究，2017/01-2018/12，2萬元，結題；
7. 第三參與人，江西省教育廳科學技術研究項目（項目編號GJJ160415）：基於納米抗體的Cry1Ac蛋白免疫傳感器檢測性能的研究，2017/01-2018/12，2萬元，結題；
學術成果
科研論文
Changjiang Li, Na Wang, Guodong Zheng*, and Licong Yang*，Oral Administration of Resveratrol-Selenium-Peptide Nanocomposites Alleviates Alzheimer's Disease-like Pathogenesis by Inhibiting Aβ Aggregation and Regulating Gut Microbiota. ACS Applied Materials & Interfaces 2021, 13, 39, 46406-46420.
Xin Li#, Licong Yang#, Meng Xu, Gaoxiang Qiao, ChangJiang Li, Lezhen Lin, Guodong Zheng *. Smilax china L. polyphenols alleviates obesity and inflammation by modulating gut microbiota in high fat/high sucrose diet-fed C57BL/6J mice. Journal of Functional Foods. 2021, 77, 104332.
Licong Yang, Yanping Zhu, Shusheng Zhong and Guodong Zheng*. Astilbin lowers the effective caffeine dose fordecreasing lipid accumulation via activating AMPK in high-fat diet-induced obese mice. Journal of the Science of Food and Agriculture. 2020, 101(2), DOI: 10.1002/jsfa.10669.
李長江，朱珊珊，王娜，聶夢嬌，鄭國棟*，楊麗聰*。Vc@SeNPs抗氧化活性評價及其對鮮切蘋果品質的影響，食品與發酵工業，2020， 46(13)：174-181.
李欣，潘永芳，王娜，楊麗聰*，鄭國棟*。菝葜醇提物對小鼠脂肪代謝酶的影響，江西農業大學學報，2020，42(02)：385-390.
Licong Yang, Yan Zhao, Yongfang Pan, Dongming Li and Guodong Zheng*. Dietary supplement of Smilax china L. ethanol extract alleviates the lipid accumulation by activating AMPK pathways in high-fat diet fed mice. Nutrition & Metabolism. 2019, 16:6.
Meng Xu#, Licong Yang#, Yanping Zhu, Mingfu Liao, Lulu Chu, Xin Li, Lezhen Lin, Guodong Zheng*. Collaborative effects of chlorogenic acid and caffeine on lipid metabolism via the AMPKα-LXRα/SREBP-1c pathway in high-fat diet-induced obese mice. Food Function. 2019, 10, 7489-7497.
Meng Xu, Hui Xue, Xin Li, Yan Zhao, Lezhen Lin,Licong Yang*, Guodong Zheng*. Chemical composition, antibacterial properties, and mechanism of Smilax china L. polyphenols. Applied Microbiology and Biotechnology. 2019, 103(21), 9013-9022.
Lulu Chu, Licong Yang*, Lezhen Lin, JingWei, NaWang, Meng Xu, Gaoxiang Qiao, Guodong Zheng*. Chemical composition, antioxidant activities of polysaccharide from Pine needle (Pinus massoniana) and hypolipidemic effect in high-fat diet-induced mice. International Journal of Biological Macromolecules. 2019, 125: 445-452.
Lulu Chu, Licong Yang*, Jingen Li, Lezhen Lin, Guodong Zheng*. Effect of Smilax china L. starch on the gel properties and interactions of calcium sulfate-induced soy protein isolate gel. International Journal of Biological Macromolecules. 2019, 135(15), 127-132.
王娜，褚路路，徐夢，喬高翔，鄭國棟，楊麗聰*。沒食子酸修飾納米硒的製備表徵及其抑菌活性研究。食品科技，2019，44(01)：302-307.
Licong Yang,Wenjun Wang, Jiguang Chen, Na Wang, Guodong Zheng*. A comparative study of resveratrol and resveratrol-functional selenium nanoparticles: inhibiting amyloid β aggregation and reactive oxygen species formation properties. Journal of Biomedical Materials Research Part A. 2018, 106(12): 3034-3041. A1二區 IF=3.231
Licong Yang, Na Wang, Guodong Zheng*. Enhanced Effect of Combining Chlorogenic Acid on Selenium Nanoparticles in Inhibiting Amyloid β Aggregation and Reactive Oxygen Species Formation In Vitro Nanoscale Research Letters. 2018, 13:303. A1二區 IF=3.125
Jiluan Liu#, Licong Yang#, Xiaojuan Zhu, Wejun Wang and Guodong Zheng*, Combinational Effect of Pine Needle Polysaccharide and Kudzu Flavonoids on Cell Differentiation and Fat Metabolism in 3T3-L1 Cells. Food Science and Technology Research. 2018, 24: 903-910.
Licong Yang, Tiantian Yin, Yanan Liu, Jing Sun, Yanhui Zhou and Jie Liu*. Gold nanoparticle-capped mesoporous silica-based H2O2-responsive controlled release system for Alzheimer’s disease treatment. Acta Biomaterialia. 2016, 46, 177-190.
Licong Yang, Jing Sun, Wenjie Xie, Yanan Liu and Jie Liu*. Dual-functional selenium nanoparticles bind to and inhibit amyloid β fiber formation in Alzheimer's disease. Journal of Materials Chemistry B. 2017, 5, 5954-5967.
Zhao Yan#, Yang Licong#, Huang Zhangwang, Lin Lezhen and Guodong Zheng, Synergistic effects of caffeine and catechins on lipid metabolism in chronically fed mice via the AMP-activated protein kinase signaling pathway. European Journal of Nutrition. 2017, 56: 2309-2318.
Licong Yang#, Qingchang Chen#, Ying Liu, Jingnan Zhang, Dongdong Sun, Yanhui Zhou and Jie Liu*. Se/Ru nanoparticles as inhibitors of metal-induced Aβ aggregation in Alzheimer’s disease. Journal of Materials Chemistry B. 2014, 2, 1977-1987.
Qingchang Chen#, Licong Yang#, Chuping Zheng, Wenjing Zheng, Jingnan Zhang, Yunshan Zhou and Jie Liu*. Mo polyoxometalate nanoclusters capable of inhibiting the aggregation of Aβ-peptide associated with Alzheimer's disease. Nanoscale. 2014, 6(12):6886-6897.
Licong Yang, Jingnan Zhang, Chuan Wang, Xiuying Qin, Qianqian Yu, Yanhui Zhou* and Jie Liu*. Interaction between 8-hydroxyquinoline ruthenium(II) complexes and basic fibroblast growth factors (bFGF): inhibiting angiogenesis and tumor growth through ERK and AKT signaling pathways.Metallomics. 2014, 41, 1734-1741.
楊麗聰，鄭國棟*， 蔣 艷，尹忠平，徐明生。咖啡鹼與茶多酚組合對小鼠肝臟脂肪代謝酶活性的影響。 中國食品學報。2011，3：14-19。
楊麗聰，鄭國棟 *，王純榮，黎冬明。咖啡鹼與兒茶素組合對小鼠體重和脂類代謝的影響。茶葉科學。2010，30（5）：374~378.
Xiu Ying Qin, Licong Yang, Fang Ling Le, Qian Qian Yu, Dong Dong Sun, Ya Nan Liu and Jie Liu*. Structures and Anti-cancer Properties of Two Binuclear Copper Complexes. Dalton Transactions. 2013, 42(41):14681-14684.
Wenjing Zheng; Licong Yang; Ying Liu; et al. Mo polyoxometalate nanoparticles inhibit tumor growth and vascular endothelial growth factor induced angiogenesis. Science and Technology of Advanced Materials, 2014,15 (3).
Xiu-Ying Qin, Ya-Nan Liu, Qian-Qian Yu, Li-Cong Yang, Ying Liu, Yan-Hui Zhou,* and Jie Liu*. Mixed-Ligand Mononuclear Copper(II) Complex: Crystal Structure and Anticancer Activity. ChemMedChem. 2014, 9(8):1665-71.
Jingnan Zhang, Xianbo Zhou, Qianqian Yu, Licong Yang, Dongdong Sun, Yanhui Zhou, and Jie Liu*. Epigallocatechin-3-gallate (EGCG)-Stabilized Selenium Nanoparticles Coated with Tet-1 Peptide To Reduce Amyloid-β Aggregation and Cytotoxicity. ACS Appl Mater Interfaces. 2014, 6, 8475-8487.
Ying Liu, Yanan Liu, Licong Yang, Chengwen Cao, Yanhui Zhou and Jie Liu*. Stabilization for loop isomers of c-myc G-quadruplex DNA and anticancer activity by ruthenium complexes. Med. Chem. Commun., 2014, 5, 1724-1728.
Dongdong Sun, Yanan Liu, Qianqian Yu, Xiuying Qin, Licong Yang, Yanhui Zhou, Lanmei Chen, Jie Liu*. Inhibition of tumor growth and vasculature and fluorescence imaging using functionalized ruthenium-thiol protected selenium nanoparticles. Biomaterials. 2014, 35(5):1572-1583.
Qian Li, Jingnan Zhang, LicongYang, Qianqian Yu, Qingchang Chen, Xiuying Qin, Fangling Le,Qianling Zhang, JieLiu*. Stabilization of G-quadruplex DNA and inhibition of telomerase activity studies of ruthenium(II) complexes. Journal of Inorganic Biochemistry. 2014,130: 122-129.
Jingnan Zhang, Qianqian Yu, QianLi, LicongYang, LanmeiChen, YanhuiZhou*, Jie Liu*. A ruthenium(II) complex capable of inducing and stabilizing bcl-2 G-quadruplex formation as a potential cancer inhibitor. Journal of Inorganic Biochemistry, 2014,134: 1-11.
Chuan Wang, Qianqian Yu, Licong Yang, Yanyu Liu, Dongdong Sun, Yongchao Huang, Yanhui Zhou, Qianling Zhang and Jie Liu. Ruthenium (II) polypyridyl complexes stabilize the bcl-2 promoter quadruplex and induce apoptosis of Hela tumor cells. Biometals. 2013, 26(3):387-402.
授權專利
(1) 楊麗聰，鄭國棟。一種兼具抑制Aβ多肽聚集及清除活性氧的納米粒子製備方法和應用，國家知識產權局，專利號：ZL201810727969.7。
(2)劉傑，楊麗聰，專利：抑制Aβ及金屬離子誘導其聚集的納米粒子及製備和應用，國家知識產權局，專利號：ZL201410150890.4。
(3) 劉傑，楊麗聰，尹田田，周艷暉。專利：一種金屬有機框架負載藥物及其製備方法和應用，國家知識產權局，專利號：ZL201510279930.X。
(4) 劉傑，楊麗聰，周艷暉。專利：一種負載CQ的納米金封堵介孔二氧化硅控制釋放系統及其製備方法和應用，國家知識產權局，專利號：ZL201510271819.6。[1]