王 應檢視原始碼討論檢視歷史
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王 應，女，現任北京大學人類疾病基因研究中心，北京大學醫學部免疫學系教授，博士生導師。
研究方向
從人類基因組編碼基因中發現潛在的新趨化因子，並進行表達、結構、功能和作用機制的研究，及其相關自主創新藥物的研發。
科研項目
2013.1-2016.12國家自然科學基金面上項目「從人類基因組編碼基因中發現潛在的新趨化因子，並進行表達、功能、機制的研究」
2012.1-2016.8 973計劃「重大心血管疾病相關GPCR新藥物靶點的基礎研究」（課題骨幹）
2013.1-2015.12高等學校博士學科點專項科研基金「新趨化因子趨化作用機制的研究」
2011.1-2013.12國家自然科學基金面上項目「CMTM8及其變異體在腫瘤細胞上皮間質轉化中的作用及機制研究」
2009.1-2010.12科技部「重大新藥創製」科技重大專項「趨化素樣因子1衍生多肽作為候選新藥的研究與開發」
2009.1-2011.12國家自然科學基金重大研究計劃培育項目「針對CKLF1與趨化因子受體的相互作用設計、發現和獲取小分子化合物及其炎症干預作用的研究」
2009.1-2011.12國家自然科學基金面上項目「CKLF1趨化作用機制的研究」
2007.1-2009.12國家自然科學基金面上項目「CMTM8在細胞因子受體轉運和信號轉導中調控作用的研究」
2003.1-2005.12國家自然科學基金面上項目「人趨化素樣因子相關蛋白2的結構與功能研究」
學術成果
論文
Xiaolei Pei, Qianying Sun, Yan Zhang, Pingzhang Wang, XinjianPeng, Changyuan Guo, Enquan Xu, Yi Zheng, Xiaoning Mo, Jing Ma, Dixin Chen, Yang Zhang, Yingmei Zhang, Quansheng Song, Shuai Guo, Taiping Shi, Zhixin Zhang, Dalong Ma, Ying Wang*. PC3-secreted microprotein is a Novel Chemoattractant Protein and Functions as a High Affinity Ligand for CC Chemokine Receptor 2. J Immunol, 2014, 192:1878-86.
Wenjuan Zhang, Michelle Mendoza, Xiaolei Pei, Sarah Mahoney, Didem Ilter, Yingmei Zhang, Dalong Ma, John Blenis*, Ying Wang*. Down-regulation of CMTM8 induces EMT-like changes and cell motility through c-MET-ERK signaling. J Biol Chem, 2012, 287, 11850-8.
Linjie Tian, Wen Li, Jiaoli Wang, Yan Zhang, Yi Zheng, Hui Qi, Xiaohuan Guo, Yingmei Zhang, Dalong Ma, Huahao Shen*, Ying Wang*. The CKLF1-C19 peptide attenuates allergic lung inflammation by inhibiting CCR3- and CCR4- mediated chemotaxis in a mouse model of asthma. Allergy, 2011, 66: 287–297.
Yi Zheng, Changyuan Guo, Yan Zhang, Hui Qi, Qianying Sun, Enquan Xu, Yingmei Zhang, Dalong Ma, Ying Wang*. Alleviation of murine allergic rhinitis by C19, a C-terminal peptide of chemokine-like factor 1 (CKLF1). International Immunopharmacology, 2011, 11, 2188-2193.
Yan Zhang; Linjie Tian; Yi Zheng; Hui Qi; Changyuan Guo; Qianying Sun; Enquan Xu; Yingmei Zhang; Dalong Ma; Ying Wang*. C-terminal peptides of Chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4. Biochemical and Biophysical Research Communications, 2011, 409: 356-361.
Ying Wang, Yingmei Zhang, Wenling Han, Dan Li, Linjie Tian, Caihua Yin, Dalong Ma*. Two C-terminal peptides of human CKLF1 interact with chemokine receptor CCR4. Int.J.Biochem.Cell.Biol. 2008, 40: 909-919.
Ying Wang, Yingmei Zhang, Xue Yang, Wenling Han, Yanan Liu, Qianmei Xu, Rui Zhao, Chunhui Di, Quansheng Song, Dalong Ma*. Chemokine-Like Factor 1 Is a Functional Ligand for CC Chemokine Receptor 4 (CCR4). Life Sciences, 2006, 78, 614-621.
Hui Qi, Yi Zheng, Enquan Xu, Changyuan Guo, Yan Zhang, Qianying Sun, Junhai Xiao, Dalong Ma, Ying Wang*. An antagonist for CCR4 alleviates murine allergic rhinitis by intranasal administration. International archives of allergy and immunology. 2012, 159, 297-305.
Dazhen Liu, Caihua Yin, Yingmei Zhang, Linjie Tian, Ting Li, Dan Li, Dalong Ma, Yinglu Guo, Ying Wang*. Human CMTM2/CKLFSF2 Enhances Androgen Receptor’s Transcriptional Activity. Chinese Science Bulletin, 2009, 54, 1050-1057.
Dan Li, Caining Jin, Bo Pang, Yingmei Zhang, Caihua Yin, Linjie Tian, Wenling Han, Dalong Ma, Ying Wang*. An alternative splice form of CMTM8 induces apoptosis. Int.J.Biochem.Cell.Bio. 2007, 39, 2107–2119.
Lin Shi, Quansheng Song, Yingmei Zhang, Yaxin Lou, Yanfang Wang, Linjie Tian, Yi Zheng, Dalong Ma, Xiaoyan Ke*and Ying Wang*. Potent antitumor activities of recombinant human PDCD5 protein in combination with chemotherapy drugs in K562 cells. Biochemical and Biophysical Research Communications, 2010, 396: 224–230.
Ying Wang, Dan Li, Hui Fan, Linjie Tian, Yingcheng Zhong, Yingmei Zhang, Lan Yuan, Caining Jin, Caihua Yin, Dalong Ma*. Cellular uptake of exogenous human PDCD5 protein. J Biol Chem, 2006, 281, 24803-24817.[1]