黃民檢視原始碼討論檢視歷史

黃民

來自 美篇 的圖片

黃民，男，1963年10月生，上海市新余市人，中山大學二級教授，博士生導師。現為中山大學臨床藥理研究所所長。中山大學藥學院原院長。享受國務院政府特殊津貼專家。

基本信息

人物說明----中山大學臨床藥理研究所所長

民 族 ---- 漢族

出生日期----1963年10月

出生地點----上海市新余市

國 籍 ---- 中國

職 業 ---- 教育科研工作者

畢業院校----上海醫科大學，香港大學

學位/學歷----博士

職 稱 ---- 教授

方向

主攻研究領域是臨床藥理學和藥代動力學，對相關藥物代謝酶和轉運蛋白及其上游調控因子的基因多態性及其與臨床藥物相互作用及臨床合理用藥方面有較深入研究。近5年，結合基因組學、表觀遺傳學、代謝組學、腸道微生物組學等技術手段，全面篩查與華法林、氯吡格雷、阿司匹林、他克莫司、環孢素、環磷酰胺、霉酚酸類藥物、硫嘌呤類藥物、丙戊酸、拉莫三嗪、吉非替尼、伊馬替尼等個體化用藥相關的"生物標誌物"，構建了劑量預測模型以及不良反應預測模型，並已在臨床指導華法林、他克莫司、環磷酰胺、硫嘌呤類藥物個體化用藥。

人物經歷

教育經歷

1979.9-1983.6 上海醫科大學本科學習，獲學士學位;

1985.9--1988.6 中山醫科大學藥理學研究生，獲碩士學位;

1994.10-1998.8 香港大學獲藥理學博士研究生。

工作經歷

1983.6-1989.11 中山醫科大學臨床藥理教研室助教;

1989.12-1994.11 中山醫科大學臨床藥理教研室講師;

1994.12-2000.11 中山醫科大學臨床藥理教研室副教授;

2002.6-2016.08 中山大學藥學院常務副院長、院長;

2000.12 - ， 中山大學臨床藥理研究所教授、所長。

2021.12 -，全國藥學專業學位研究生教育指導委員會委員

社會兼職

擔任國家藥典委員、國務院學位委員會第七屆藥學學科評議組成員、中國藥理學會常務理事、臨床藥理專業委員會主任委員、藥物代謝專業委員會委員(理事)、International Society for the Study of Xenobiotics(ISSX)財經委員會委員、廣東省科協常委、廣東省藥理學會名譽理事長、廣東省藥學會副理事長、廣東省藥物評價及合理用藥專業委員會主任委員;"DrugMetabolismandDisposition "、"中國藥學英文版"、 "藥學學報"、"中國臨床藥理學雜誌"、"中國醫藥工業雜誌"、"中藥新藥與臨床藥理" 、"中國臨床藥理學與治療學雜誌"、"中國藥學雜誌英文版"、"今日藥學"雜誌編委;國家食品藥品監督管理總局藥品審評專家庫專家、廣東省藥品審評專家庫專家。

學術成果

科研項目

1.冠心病個體化用藥靶標發現與組學新技術研發(國家重點研究計劃項目，400萬圓，2017~2019，項目編號2017YFC0909300);

2.基於多組學的丙戊酸鈉個體化給藥方案的生物標誌物的發現與確證(國家自然科學基金重點項目，280萬圓，2018~2022，項目編號81730103)

3.重大疾病新靶點與藥物研究創新引智基地(111計劃，900萬圓，2016-2020，基地編號B16047);

4.基於基因組學和代謝組學的硫嘌呤類藥物個體化給藥(國家自然科學基金，58萬圓，2016.01-2019.12，項目編號81573507);

5.基於藥物基因組學及表觀遺傳調控的環孢素/他克莫司個體化用藥研究((國家自然國際合作項目，280萬圓，2014.01-2018.12，項目編號81320108027)

6.紅豆杉口服抗腫瘤5類新藥的開發研究(廣東省重大科技專項，150萬圓2013.01-2014.04，項目編號2012A080202013)

7.個體化用藥相關重要生物技術標誌物及其新型檢測試劑盒研發關鍵技術(十二五重大專項，500萬圓，2012.01~2015.12，項目編號2012ZX09506001-004)

8.廣東省新藥設計與評價重點實驗室(廣東省科技計劃，500萬圓，2011年，項目編號2011A060901014)

9.多基因"網絡"調控作用下環孢素/他克莫司個體化用藥研究.(國家自然科學基金，37萬圓，2011.01~2013.12，項目編號81072708)

10.臨床前藥物代謝動力學技術平台.(國家"重大新藥創製"科技重大專項1500萬圓，負責330萬圓，2009.01~2010.12，項目編號2009ZX09304-003)

11.新藥臨床評價研究技術平台.(國家"重大新藥創製"科技重大專項1200萬圓，負責166萬圓，2008.01~2010.12，項目編號2008ZX09312)

12.相關代謝酶基因多態性與環磷酰胺在SLE病人中療效和不良反應相關性研究(國家自然科學基金，32萬圓，2009.01~2011.12，項目編號30873124)

13.器官移植患者相關基因單倍型多態性與免疫抑制劑個體化作用(廣東省科技計劃項目基金，4萬圓，2007年，項目編號2007B031511001)

14.創新藥物研究篩選與評價科技創新平台建設(教育部II期985重點建設專項，2200萬圓，2005年，平台負責人)

15.應用TPMT表型及基因型指導硫嘌呤類藥物的臨床使用(國家自然科學基金，28萬圓，2005年，項目編號30572231)

16.廣州新藥臨床前評價研究技術平台(廣州市重大項目，500萬圓，2004年，項目編號2004Z1-E4051)

17.中華民族硫嘌呤甲基轉移酶基因多態性研究(教育部博士點基金，6萬圓，2003年，項目編號20030558081)

18.應用硫嘌呤甲基轉移酶基因型預測嘌呤類藥物毒性療效(廣東省自然科學基金重點項目，15萬圓，2003年，項目編號36622)

19.臨床試驗關鍵技術及平台研究(863)(國家科技部，150萬圓，2002年，分題負責)

20.TPMT基因多態性與硫嘌呤類毒性和療效關係(國家自然科學基金，16萬圓，2001年，項目編號30171098)

發表論著

論述:

1.普通高等教育"十二五"規劃教材《臨床藥理學》，清華大學出版社，2012.01.(副主編);

2.普通高等教育"十一五"國家規劃教材 案例版《臨床藥物代謝動力學》，科學出版社，2009.12.(副主編)

3.普通高等教育"十一五"國家級規劃教材《臨床藥理學》，高等教育出版社，2010.01(參編)

4.《英漢化學藥物詞典》，商務出版社，2010.03.(主編)

5.《臨床藥理學》，中山大學出版社.，2007.08.(主編)

6.《藥物臨床試驗標準操作規程實用指南》，廣東科技出版社，2004.10.(主編)

7.《臨床藥代動力學基礎與應用》，鄭州大學出版社，2002.11.(副主編)

8.《藥理學》，北京大學醫學出版社，2004.04.(參編)

9.高新技術科普叢書《量體裁藥不是夢--從基因到個體化用藥》，廣東科技出版社，2011.05.(主編)

10.普通高等教育"十一五"國家級規劃教材《臨床藥物代謝動力學》，科學出版社，2016(副主編)

11.國家衛生和計劃生育委員會"十二五"規劃教材、全國高等醫藥教材建設委員會"十二五"規劃教材、全國高等學校臨床藥學專業第二輪規劃教材《臨床藥理學》，人民衛生出版社，2014.10(參編)

12.《臨床藥理學》，中山大學出版社，2017.07. (主編)

13.高等院校"十三五"規劃/創新實驗教材《藥代動力學實驗教程》，中山大學出版社，2017.04,(主編)

14.全國高等醫藥院校"十三五"規劃教材《臨床藥理學》，高等教育出版社，2017.07.(參編)

近三年發表的論文:

1.Zhuang W,Qiu HB,Chen XM,Yuan XH,Yang LF,Sun XW,Zhou XJ,Huang M,Wang XD*,Zhou ZW*. Simultaneous quantification of imatinib and its main metabolite N-demethyl-imatinib in human plasma by liquid chromatography-tandem mass spectrometry and its application to therapeutic drug monitoring in patients with gastrointestinal stromal tumor.Biomedical Chromatography,2017,31(12):1-11.

2.Li JL, Chen SY, Qin XL, Fu Q, Bi HC, Zhang Y, Wang XD, Liu LS, Wang CX*,Huang M*. Wuzhi Tablet (Schisandra sphenanthera Extract) is a Promising Tacrolimus-Sparing Agent for Renal Transplant Recipients Who are CYP3A5 Expressers: a Two-Phase Prospective Study.Drug Metabolism and disposition,2017,45(11):1114-1119.

3.Li X, Sun JH, Fan XM, Guan LH, Li DS, Zhou YW, Zeng XZ, Chen YX, Zhang HZ, Xu LQ, Jiang FL,Huang M, Bi HC*. Schisandrol B promotes liver regeneration after partial hepatectomy in mice.European journal of pharmacology,818:96-102.

4.Deng Y, Zhuang JL, Wu JG, Chen JY, Ding L, Wang XD, Huang LH, Zeng GX, Chen J, Ma ZF, Chen X, Zhong GP*,Huang M, Zhao XL.A bioequivalence study of two memantine formulations in healthy Chinese male volunteers.International Journal of Clinical Pharmacology and Therapeutics.2017,55(10):832-838.

5.Qiu HB, Zhuang W, Wang XD,Huang M, Zhou ZW*. Association between genetic polymorphisms and variation of imatinib pharmacokinetics in gastrointestinal stromal tumors.Chinese journal of gastrointestinal surgery.2017,20(9):1031-1034.

6.Chen P, Li DS, Chen YX, Sun JH, Fu KL, Guan LH, Zhang HZ, Jiang YM, Li X, Zeng XZ, Chen X,Huang M, Bi HC*. p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice.British journal of pharmacology,2017,174(23):4345-4361.

7.Zhang HZ, Gao Y, Sun JH, Fan SC, Yao XP, Ran XR, Zheng CQ,Huang M, Bi HC*. Optimization of lipid extraction and analytical protocols for UHPLC-ESI-HRMS-based lipidomic analysis of adherent mammalian cancer cells.Analytical and Bioanalytical Chemistry.2017,409(22):5349-5358.

8.Zeng XZ, Li X, Xu CS, Jiang FL, Mo YF, Fan XM, Li YT, Jiang YM, Li DS,Huang M, Bi HC*.Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice.Acta pharmaceutica Sinica. B.2017,7(5):583-592.

9.Chao K, Wang XD, Cao Q, Qian JM, Wu KC, Zhu, X, Yang H, Liang J, Lin L, Huang ZC, Zhang Y, Huang YB, Sun YH, Xue XM,Huang M, Hu, PJ, Lan P, Gao X*. Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.Inflammatory Bowel Disease.2017,23(9):1582-1599.

10.WangY,ZhouC,GaoH,LiGX,Li D,Liu PQ,Huang M,Shen XY*,Liu L*.Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation.Biochemical Pharmacology.2017Aug,138:119-129.

11.Liang YB,Huang M,Jiang X,Liu Q,Chang X,Guo Y*.The neuroprotective effects of Berberine against amyloid β-protein-induced apoptosis in primary cultured hippocampal neurons via mitochondria-related caspase pathway.Neuroscience Letters.2017Aug,

12.Zhang Huizhen;GaoYue;SunJiahong;FanShicheng;YaoXinpeng;RanXiaorong;ZhengChuanqi;Huang Min*;BiHuichang*.Optimization of lipid extraction and analytical protocols for UHPLC-ESI-HRMS-based lipidomic analysis of adherent mammalian cancer cells.Analytical and bioanalytical chemistry.2017Sept,409(22):5349–5358.

13.Bai XP,Hong WP,Cai PH,Chen YB,Xu CC,Cao D,Yu WB,Zhao ZX,Huang Min,Jin J*.Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis.Toxicology and Applied Pharmacology.2017June,324:12–25.

14.Lu Liang,Zhang Sulin, Li Cuixian,Zhou Chun,Li Dong,Liu Peiqing,Huang Min,Shen Xiaoyan.Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation.CELL DEATH & DISEASE.2017May,8:e2767.

15.Li Yuhua,Huang Ling,Sun Jiahong,Wei Xiaohua,Wen Jinhua,Zhong Guoping,Huang Min,Bi Huichang*.Mulberroside A suppresses PXR-mediated transactivation and gene expression of P-gp in LS174T cells.JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY.2017Sept,31(5):e21884.

16.Hu Bingfang,Li Yujin,Gao Li,Guo Yan,Zhang Yiwen,Chai Xiaojuan,Xu Meishu,Yan Jiong,Lu Peipei,Ren Songrong,Zeng Su,Liu Yulan,Xie Wen,Huang Min*.Hepatic Induction of Fatty Acid Binding Protein 4 Plays a Pathogenic Role in Sepsis inMice.AMERICAN JOURNAL OF PATHOLOGY.2017Sept,187(5):1059-1067.

17.Zeng Hang,Jiang Yiming,Chen Pan,Fan Xiaomei,Li Dongshun,Liu Aiming,Ma Xiaochao,Xie Wen,Liu Peiqing,Gonzalez Frank J,Huang Min*,Bi Huichang*.Schisandrol B protects against cholestatic liver injury through pregnane X receptors.BRITISH JOURNAL OF PHARMACOLOGY.2017Apr,174(8):672-688.

18.Chen Yixin,Wang Yongtao,Huang Yaoyao,Zeng Hang,Hu Bingfang,Guan Lihuan,Zhang Huizhen,Yu Ai-Ming,Johnson Caroline H,Gonzalez Frank J,Huang Min,Bi Huichang.PPAR alpha regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C.CARCINOGENESIS. 2017Apr,38(4):474-483.

19.Wen Dingsheng,Guo Jing,Jiang Fulin,Huang Caishun,Zhao Zhenzhen,Lu Gui,Chen Jiangying,Qin Liuyun,Li Zhangwei,Wang Xueding,Deng Zhuoan,Huang Min,Chi Chan Albert Sun,On Tang Johnny Cheuk,Zhong Guoping.A rapid and sensitive UHPLC-MS/MS method for quantification of 83b1 in plasma and its application to bioavailability study in rats.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2017Feb,134:

20.Ni, Guanzhong;Qin, Jiaming; Chen, Ziyi; Li, Hongliang; Zhou, Jueqian;Huang, Min; Zhou, Liemin.Associations between genetic variation in one-carbon metabolism and leukocyte DNA methylation in valproate-treated patients with epilepsy.Clinical Nutrition, 2017Jan,20.

21.Zhang, Huizhen; Jiang, Yiming ; Wu, Jingjing ; Zheng, Chuanqi; Ran, Xiaorong; Li, Dongshun;Huang, Min; Bi, Huichang. Metabolic mapping of Schisandra sphenanthera extract and its active lignans using a metabolomic approach based on ultra high performance liquid chromatography with high-resolution mass spectrometry.Journal of Separation Science,2017,40(2):574.

22.Li Yu-hua; Huang Ling; Wei Xiao-hua; Wen Jin-hua; Zhong Guo-ping;Huang Min; Bi Hui-chang.Regulation of P-glycoprotein gene expression by PKC/NF-κB-PXR signaling pathway.Acta Pharmaceutica Sinica. 2017,52(1): 51-57

23.Qin Li; Li Jiali; Liu Xiaoman; Chen Xutao; Liu Shu; Liu Longshan; Wang Changxi;Huang Min.Associations of VDR polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients.Acta Pharmaceutica Sinica.2017,52 (5):760-765

24.Peng Ling-ling, Zhao Yuan-qi, Zhou Zi-yi, Jin Jing, Zhao Min, Chen Xin-meng,Chen Ling-yan, Cai Ye-feng*, LI Jia-li*,Huang Min*.Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy. Acta Pharmacologica Sinica 2016: 1–7.

25.Chen Xin-meng, Zhao Zhong-xiang, Chen Yi-bei, Gou Xiao-li, Zhou Zi-yi, Zhong Guo-ping, Cai Ye-feng,Huang Min, Jin Jing *, Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats. Journal of Ethnopharmacology 192(2016)362–369.

26.Bai Xu-peng, Chen Yi-bei, Hou Xiang-yu,Huang Min* & Jin Jing *; Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters . Drug Metab Rev. 2016 Jun 20:1-27.

27.Wang Wen-wen, Guan Cui-wen, Sun Xiao-zhe, Zhao Zhong-xiang, Li Jia, Fu Xin-lu, Qiu Yu-wen,Huang Min, Jin Jing ∗, Zhi-ying Huang∗; Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway. Phytomedicine. 2016 Jun 1;23(6):589-96.

28.LiuRui,ZhouZi-yi,ChenYi-bei, LiJia-li,YuWei-bang,ChenXin-meng,ZhaoMin, ZhaoYuan-qi, CaiYe-feng*,JinJing*, andHuangMin*.Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke. Acta Pharmacol Sin. 2016 Jul;37(7):882-8.

29.Ma Y, Xin S, Huang M, Yang Y, Zhu C, Zhao H, Zhang Y, Chen L, Zhao Y, Li J, Zhuang W, Zhu X, Zhang L * and Wang X *. Determinants of Gefitinib toxicity in advanced non-small cell lung cancer (NSCLC): a pharmacogenomic study of metabolic enzymes and transporters. The pharmacogenomics journal 2016 Apr: 1–6.

30.Yu Tao, Wang Yong-tao, Zhang Hui-zhen, Caroline H. Johnson, Jiang Yi-ming, Li Xiang-jun, Wu Ze-ming, Liu Tian, Kristopher W. Krausz, Aiming Yu, Frank J. Gonzalez,Huang Min, Bi Hui-chang *.Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells. Anal Bioanal Chem. 2016 Jun;408(16):4267-73.

31.Zhao Zhen-zhen, Huang Ling-jie, Gou Xiao-li, Li Zhang-wei, Chen Jiang-ying, Wen Ding-sheng, Jiang Fu-lin, Lu Gui, Bi Hui-chang,Huang Min, Zhong Guo-ping *. Determination of a novel Aurora-A (AurA) kinase AKI603 by UPLC-MS/MS and its application to a bioavailability study in rat. J Pharm Biomed Anal. 2016 Jun 5;125:303-9.

32.TanYin-he,SiXiao-qing, ZhongLu-lu,FengXin,YangXin-min, HuangMin*, and WuChuan-bin*Development and validation of dissolution testings in acidic media for rabeprazole sodium delayed-release capsules. Drug Dev Ind Pharm. 2016 Oct;42(10):1669-77.

33.LiXi, Fan Xiao-mei, Li Dong-shun, Zeng Xue-zhen, Zeng Hang, Wang Yong-tao, Zhou Ya-wen, Chen Yi-xin,Huang Min*, and Bi Hui-chang *. Schisandra sphenanthera Extract Facilitates Liver Regeneration after Partial Hepatectomy in Mice. Drug Metab Dispos. 2016 May;44(5):647-52.

34.Xu Chen-shu, Huang,Min, Bi Hui-chang *.PXR- and CAR-mediated herbal effect on human diseases. Biochim Biophys Acta. 2016 Sep;1859(9):1121-9.

35.Jiang Yi-ming, Wang Ying, Tan Hua-sen, Yu Tao, Fan Xiao-mei, Chen Pan, Zeng Hang,Huang Min,* and Bi Hui-chang *.Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway. Acta Pharmacol Sin. 2016 Mar;37(3):382-9.

36.Tan Hua-sen, Xu Chen-shu, Zeng Hang, Wang Ying, Li Ying-mei, Fan Xiao-mei, Chen Pan, Jiang Yi-ming, Chen Xiao,Huang Min*, Bi Hui-chang *. SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells . J Pharmacol Sci. 2016 Feb;130(2):66-71.

37.Guo Yan, Hu Bing-fang, Xie Yang, Timothy R. Billiar,d Jason L. Sperry,Huang Min, and Xie Wen *. Regulation of drug-metabolizing enzymes by local and systemic liver injuries. Expert Opin Drug Metab Toxicol. 2016;12(3):245-51.

38.Zhao Z., Chen J., Peng W., Wang X., Chen Z., Tang H., Liang Y., Ma Z., Chen J., Chen X., Zhong G. *, Huang M.. Single- and Multiple-dose Pharmacokinetic, Safety and Tolerability Study of Mildronate Injection in Healthy Chinese Subjects Pharmacokinetic of Mildronate Injection. Drug Res (Stuttg). 2016 May;66(5):251-6.

39.Zeng Hang, Li Dong-shun, Qin Xiao-ling, Chen Pan, Tan Hua-sen, Zeng Xue-zhen, Li Xi, Fan Xiao-mei, Jiang Yi-ming, Zhou Ya-wen, Chen Yi-xin, Wang Ying,Huang Min*,and Bi Hui-chang *. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration. Drug Metab Dispos.2016 Mar;44(3):337-42.

40.Shu Wen-ying, Guan Su, Yang Xiu-yan, Liang Liu-qin, Li Jia-li, Chen Zhuo-jia, Zhang Yu, Chen Ling-yan, Wang Xue-ding *,Huang Min*. Genetic markers in CYP2C19 and CYP2B6 for prediction of cyclophosphamide's 4-hydroxylation, efficacy and side effects in Chinese patients with systemic lupus erythematosus. Br J Clin Pharmacol. 2016 Feb;81(2):327-40

41.Zhu X, Wang XD*, Chao K, Zhi M, Zheng H, Ruan HL, Xin S, Ding N, Hu PJ, Huang M, Gao X*. NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease. Aliment Pharmacol Ther. 2016 Sep 8.

42.Chen Pan, Li Jingjie , Fan Xiao-mei , Zeng Hang, Deng Rong-rong , Li Dong-shun,Huang Min, Bi Hui-chang * ,Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism.Eur J Pharmacol.2015 Oct 15;765:131-9.

43.Zhuang Jia-lang , Chen Jiang-ying, Wang Xue-ding , Pang Yin, Bi Hui-chang ,Huang Li-hui ,Zeng Gui-xiong , Liao Xiao-xing , Ma Zhong-fu, Chen Xiao ,Zhong Guo-ping* ,Huang Min,Zhao Xiang-lan .Validation of a HPLC-ESI MS/MS method for the determination of clonidine in human plasma and its application in a bioequivalence study in Chinese healthy volunteers.Biomed Chromatogr.2015 Oct;29(10):1506-13.

44.Hu Bing-fang, Guo Yan, Wojciech G. Garbacz, Jiang Meng-xi , Xu Mei-shu , Huang Hai , Allan Tsung, Timothy R. Billiar, Sadeesh K. Ramakrishnan, Yatrik M. Shah, Karen S.L. Lam,Huang Min*, Xie Wen *, Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury.J Hepatol.2015 Oct;63(4):855-62.

45.Liu Hui *, Ding Liang,Zhang Fang-bin ,Zhang Yu ,Gao Xiang ,Hu Pin-jin , Bi Hui-chang,Huang Min, The impact of glutathione S-transferase genotype and phenotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases.J Pharmacol Sci.2015 Oct;129(2):95-100.

46.Jin Jing,Sun Xiao-zhe, Zhao Zhong-xiang, Wang Wen-wen, Qiu Yu-wen, Fu Xin-lu,Huang Min, Huang Zhi-ying*.Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity.Phytomedicine.2015 Sep 15;22(10):894-901.

47.Ma Li-ping, QinYa-hong, Shen Zhuo-wei,Bi Hui-chang , Hu Hai-yong,Huang Min, Zhou Hui , Yu Lu-shan, Jiang Hui-di, Zeng Su*, .Aristolochic acid I is a substrate of BCRP but not P-glycoprotein or MRP2.J Ethnopharmacol.2015 Aug 22;172:430-5.

48.Chai Xiao-juan, Guo Yan, Jiang Meng-xi, Hu Bing-fang, Li Zhi-gang, Fan Jie , Deng Mei-hong, Timothy R. Billiar, Heidi R. Kucera, Nilesh W. Gaikwad, Xu Mei-shu, Lu Pei-pei, Yan Jiong, Fu Hai-yan, Liu You-hua,Yu Lu-shan,Huang Min,Zeng Su *, Xie Wen*.Oestrogen sulfotransferase ablation sensitizes mice to sepsis.Nat Commun.2015 Aug 10;6:7979.

49.Zhou Ya-fang, Wang Xue-ding, Li Hong-liang, Zhang Jie, Chen Ziyi , Xie Wen, Zhang Jin-xin, Li Jia-li, Zhou Lie-min * ,Huang Min*. Polymorphisms of ABCG2, ABCB1 and HNF4α are associated with Lamotrigine trough concentrations in epilepsy patients.Drug Metab Pharmacokinet.2015 Aug;30(4):282-7.

50.Xin Shuang, Zhao Yuan-yuan,Wang Xue-ding , Huang Yan, Zhang Jing , Guo Ying,Li Jia-li , Li Hong-liang, Ma Yu-xiang, Chen Ling-yan, Hu Zhi-huang,Huang Min,*, Zhang Li*. The Dissociation of Gefitinib Trough Concentration and Clinical Outcome in NSCLC Patients with EGFR Sensitive Mutations.Sci Rep.2015 Jul 31;5:12675.

51.Wang Ying, Jiang Yi-ming, Fan Xiao-mei, Tan Hua-sen, Zeng Hang, Wang Yong-tao, Chen Pan,Huang Min, Bi Hui-chang*. Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways.Toxicol Lett.2015 Jul 16;236(2):82-9.

52.Wang Yi-xi , Li Jia-li, Wang Xue-ding ,Zhang Yu ,Wang Chang-xi *,Huang Min*. Diltiazem augments the influence of MDR1 genotype status on cyclosporine concentration in Chinese patients with renal transplantation.Acta Pharmacol Sin.2015 Jul;36(7):855-62.

53.Li Mei-Mei, Balasubrahmanyam Addepalli, Tu Mei-Juan,Chen Qiu-Xia , Wang Wei-Peng, Patrick A. Limbach, Janine M. LaSalle, Zeng Su,Huang Min, Yu Ai-Ming*. Chimeric MicroRNA-1291 Biosynthesized Efficiently in Escherichia coli Is Effective to Reduce Target Gene Expression in Human Carcinoma Cells and Improve Chemosensitivity.Drug Metab Dispos.2015 Jul;43(7):1129-36.

54.GuoYan, Hu Bing-fang, Huang Hai, Allan Tsung, Nilesh W. Gaikwad*, Xu Mei-shu,Jiang Meng-xi , Ren Song-rong, Fan Jie , Timothy R. Billiar,Huang Min*, Xie Wen*. Estrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion Injury.J Biol Chem.2015 Jun 5;290(23):14754-64.

55.Wang Ying, Wang Shao-gui, Li Yan-mei, Jiang Jian-Min, Zhou Chun, Li Cui-xian, Li Dong, Lu Liang, Liu Pei-qing,Huang Min, Shen Xiao-yan* , Therapeutic effect of Cryptotanshinone on collagen-induced arthritis in rats via inhibiting nuclear factor kappa B signaling pathway.Transl Res.2015 Jun;165(6):704-16.

56.Jin Jing, Li Mei, Zhao Zhong-xiang, Suna Xiao-zhe, Li Jia, Wang Wen-wen,Huang Min, Huang Zhi-ying*. Protective effect of Wuzhi tablet (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response.Phytomedicine.2015 May 15;22(5):528-35.

57.Shu Wen-ying,Li Jia-li,Wang Xue-ding,Huang Min*. Pharmacogenomics and personalized medicine: a review focused on their application in the Chinese population.Acta Pharmacol Sin.2015 May;36(5):535-43.

58.Xie Xiao-chun , Li Jun, Wang Hong-yang, Li Hong-liang, Liu Jing, Fu Qian, Huang Jia-wen, Zhu Chen, Zhong Guo-ping, Wang Xue-ding,Sun Ping-ping ,Huang Min, Wang Chang-xi*, Li Jia-li *. Associations of UDP-glucuronosyltransferases polymorphisms with mycophenolate mofetil pharmacokinetics in Chinese renal transplant patients.Acta Pharmacol Sin.2015 May;36(5):644-50.

59.Hou Xiang-yu, Bai Xu-peng, Gou Xiao-li, Zeng Hang, Xia Chen, Zhuang Wei, Chen Xin-meng, Zhao Zhong-xiang,Huang Min, Jin Jing*. 3',4',5',5,7-pentamethoxyflavone sensitizes Cisplatin-resistant A549 cells to Cisplatin by inhibition of Nrf2 pathway.Mol Cells.2015May;38(5):396-401.

60.Jiang Yi-ming, Fan Xiao-mei,Wang Ying , Tan Hua-sen, Chen Pan, Zeng Hang,Huang Min*, Bi Hui-chang*. Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation.Chem Biol Interact.2015 Apr 25;231:83-9.

61.Liu Xiao-man,Li Jia-li , Fu Qian, Liu Shu, Zhang Yu, Wang Xue-ding,Wang Hong-yang , Li Jun,Zhu Chen , Wang Chang-xi*,Huang Min*. Associations of HSD11B1 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients with prednisone combined therapy.Drug Metab Dispos.2015 Apr;43(4):455-8.

62.Liu Bin , Gou Xiao-li, Bai Xu-peng, Hou Xiang-yu, Li Dong-shun, Zhong Guo-ping, Jin Jing*, Huang Min*. Simultaneous determination of seven taxoids in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Taxus yunnanensis extracts.J Pharm Biomed Anal.2015 Mar 25;107:346-54.

63.Li Hong-liang, Wang Xue-ding, Zhou Ya-fang, Ni Guan-zhong , Su Qi-biao, Chen Zi-yi, Chen Zhuo-jia, Li Jia-li , Chen Xin-meng , Hou Xiang-yu, Xie Wen, Xin Shuang,,Zhou Lie-min,Huang Min*. Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid.Int J Neuropsychopharmacol.2015 Mar 3;18(7):pyv021.

64.Huang Na, Situ Bing, Chen Xiao, Liu Jianqiao, Yan Peng-ke, Kang Xin-huang, Kong Song-zhi, Huang Min*. Meta-analysis of estradiol for luteal phase support in in vitro fertilization/intracytoplasmic sperm injection.Fertil Steril.2015 Feb;103(2):367-73.e5.

65.Xia Chen , Bai Xu-peng , Hou Xiang-yu , Gou Xiao-li , Wang Yong-tao , Zeng Hang,Huang Min,Jin Jing *. Cryptotanshinone Reverses Cisplatin Resistance of Human Lung Carcinoma A549 Cells through Down-Regulating Nrf2 Pathway.Cell Physiol Biochem.2015;37(2):816-24.

66.Yu Tao, Wang Yong-Tao, Chen Pan, Li Yu-Hua, Chen Yi-Xin, Zeng Hang, Yu Ai-Ming,Huang Min, Bi Hui-Chang*. Effects of nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress.Cell Physiol Biochem.2015;35(2):710-21.

67.Zuo Zhong*,Huang Min, Isadore Kanfer, Moses S. S. Chow, William C. S. Cho. Herb-drug interactions: systematic review, mechanisms, and therapies.Evid Based Complement Alternat Med.2015 Feb;2015:239150.

68.Li Jia-li, Liu Shu, Fu Qian, Zhang Yu , Wang Xue-ding, Liu Xiao-man, Liu Long-shan, Wang Chang-xi,Huang Min*. Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant crecipients.Pharmacogenomics.2015 August;16(12):1355-65.

69.46. Ni Guan-zhong，Qin Jia-ming, Li Hongliang, Chen Ziyi, Zhou Yafang, Fang Ziyan, ChenYi-shu , Zhou Jue-qian,Huang Min, Zhou Lie-min*. Effects of antiepileptic drug monotherapy on one-carbon metabolism and DNA methylation in patients with epilepsy. PLoS One. 2015 Apr 27;10(4):e0125656.

Jiang Yi-ming, Fan Xiao-mei, Wang Ying, Chen Pan, Zeng Hang, Tan Hua-sen, Gonzalez Frank J,Huang Min, Bi Hui-chang*. Schisandrol B Protects Against Acetaminophen-Induced Hepatotoxicity by Inhibition of CYP-Mediated Bioactivation and Regulation of Liver Regeneration. Toxicol Sci. 2015 Jan;143(1):107-15